Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC061
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-10 09:21
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment new patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 25 individuals with a value less than 0.6 were subsequently diagnosed with PD. That is, 59.52% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.6 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 14, 'TN': 12, 'TP': 28, 'FP': 18}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 39, 'TN': 27, 'TP': 3, 'FP': 3}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 17, 'TN': 9, 'TP': 25, 'FP': 21}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 13
timePerCircleMean 5.47077
timePerCircleCoV 0.402869
timePerCircleSlope 0.0143821
meanError 4.4526
tremorFreq 6.34766
tremorRelPower 31.7755
tremorGyroAmpMean 0.0258037
tremorGyroAmpSlope -0.00661249
tremorGyroAmpCoV 0.657436
tremorCoordAmpMean 0.0652097
tremorCoordAmpSlope -0.00254755
tremorCoordAmpCoV 0.582736
tremorAccAmpMean 0.0628106
tremorAccAmpSlope -0.000968142
tremorAccAmpCoV 0.314182
tremorPcRelVar 0.701379
tremorPcX -0.442991
tremorPcY 0.896526

Circle Segment 1

Duration 5.12 s, Accuracy Estimate 2.729 (lower is better)

Circle Segment 2

Duration 3.12 s, Accuracy Estimate 6.335 (lower is better)

Circle Segment 3

Duration 3.04 s, Accuracy Estimate 7.403 (lower is better)

Circle Segment 4

Duration 3.08 s, Accuracy Estimate 7.614 (lower is better)

Circle Segment 5

Duration 9.72 s, Accuracy Estimate 5.238 (lower is better)

Circle Segment 6

Duration 8.48 s, Accuracy Estimate 5.281 (lower is better)

Circle Segment 7

Duration 7.56 s, Accuracy Estimate 4.214 (lower is better)

Circle Segment 8

Duration 5.12 s, Accuracy Estimate 3.96 (lower is better)

Circle Segment 9

Duration 4.48 s, Accuracy Estimate 2.91 (lower is better)

Circle Segment 10

Duration 3.92 s, Accuracy Estimate 2.079 (lower is better)

Circle Segment 11

Duration 7.68 s, Accuracy Estimate 3.698 (lower is better)

Circle Segment 12

Duration 5.4 s, Accuracy Estimate 2.924 (lower is better)

Circle Segment 13

Duration 4.4 s, Accuracy Estimate 3.497 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 17.496
timePerSpiralCoV 0.159485
timePerSpiralSlope -0.0448102
meanError 4.47409
tremorFreq 6.44531
tremorRelPower 30.8109
tremorGyroAmpMean 0.0371221
tremorGyroAmpSlope 0.00159631
tremorGyroAmpCoV 0.38923
tremorCoordAmpMean 0.0783582
tremorCoordAmpSlope 0.00165542
tremorCoordAmpCoV 0.363244
tremorAccAmpMean 0.06362
tremorAccAmpSlope 0.00131363
tremorAccAmpCoV 0.352994
tremorPcRelVar 0.661544
tremorPcX -0.626569
tremorPcY -0.779366

Spiral Segment 1

Duration 20.2 s, Accuracy Estimate 5.278 (lower is better)

Spiral Segment 2

Duration 17.92 s, Accuracy Estimate 8.411 (lower is better)

Spiral Segment 3

Duration 21.24 s, Accuracy Estimate 3.426 (lower is better)

Spiral Segment 4

Duration 19.04 s, Accuracy Estimate 2.941 (lower is better)

Spiral Segment 5

Duration 18.88 s, Accuracy Estimate 3.166 (lower is better)

Spiral Segment 6

Duration 17.44 s, Accuracy Estimate 3.155 (lower is better)

Spiral Segment 7

Duration 17.08 s, Accuracy Estimate 3.398 (lower is better)

Spiral Segment 8

Duration 16.72 s, Accuracy Estimate 3.156 (lower is better)

Spiral Segment 9

Duration 15.08 s, Accuracy Estimate 4.078 (lower is better)

Spiral Segment 10

Duration 11.36 s, Accuracy Estimate 7.732 (lower is better)

Elel

eDurationMean 0.569857
eDurationStd 0.095143
eDurationStdnorm 0.166959
eDurationMedian 0.56
eDurationQuartdelta 0.10875
eDurationQuartdeltanorm 0.194196
eDurationKurt 2.90822
eDurationTrenddiff -0.035
eDurationTrendratio 0.940171
eWidthMean 5.27503
eWidthStd 1.24643
eWidthStdnorm 0.23629
eWidthMedian 5.031
eWidthQuartdelta 2.01825
eWidthQuartdeltanorm 0.401163
eWidthKurt 2.28172
eWidthTrenddiff 0.468
eWidthTrendratio 1.1
eHeightMean 13.2377
eHeightStd 3.09138
eHeightStdnorm 0.233528
eHeightMedian 12.87
eHeightQuartdelta 5.11875
eHeightQuartdeltanorm 0.397727
eHeightKurt 1.81862
eHeightTrenddiff 2.574
eHeightTrendratio 1.20561
eAspectMean 0.410527
eAspectStd 0.105788
eAspectStdnorm 0.257687
eAspectMedian 0.368932
eAspectQuartdelta 0.123805
eAspectQuartdeltanorm 0.335578
eAspectKurt 4.80179
eAspectTrenddiff 0.0334225
eAspectTrendratio 1.09191
eSlantMean -0.116052
eSlantStd 0.147075
eSlantStdnorm -1.26733
eSlantMedian -0.0769231
eSlantQuartdelta 0.162967
eSlantQuartdeltanorm -2.11857
eSlantKurt 4.5764
eSlantTrenddiff 0.0828852
eRtopMean 0.645327
eRtopStd 0.130298
eRtopStdnorm 0.201911
eRtopMedian 0.672414
eRtopQuartdelta 0.178743
eRtopQuartdeltanorm 0.265822
eRtopKurt 2.73806
eRtopTrenddiff 0.0623583
eRbotMean 0.947084
eRbotStd 0.354402
eRbotStdnorm 0.374203
eRbotMedian 0.888889
eRbotQuartdelta 0.338254
eRbotQuartdeltanorm 0.380536
eRbotKurt 3.69975
eRbotTrenddiff -0.13617
eRrightMean 0.800738
eRrightStd 0.0973751
eRrightStdnorm 0.121607
eRrightMedian 0.815603
eRrightQuartdelta 0.099001
eRrightQuartdeltanorm 0.121384
eRrightKurt 7.39249
eRrightTrenddiff 0.0534145
eRleftMean 0.426784
eRleftStd 0.123359
eRleftStdnorm 0.289043
eRleftMedian 0.392523
eRleftQuartdelta 0.144087
eRleftQuartdeltanorm 0.36708
eRleftKurt 2.99622
eRleftTrenddiff -0.0355581
lDurationMean 0.771176
lDurationStd 0.149261
lDurationStdnorm 0.19355
lDurationMedian 0.7625
lDurationQuartdelta 0.2
lDurationQuartdeltanorm 0.262295
lDurationKurt 3.18548
lDurationTrenddiff -0.14
lDurationTrendratio 0.825
lWidthMean 7.51553
lWidthStd 1.94056
lWidthStdnorm 0.258207
lWidthMedian 7.371
lWidthQuartdelta 2.574
lWidthQuartdeltanorm 0.349206
lWidthKurt 2.7861
lWidthTrenddiff 1.404
lWidthTrendratio 1.21053
lHeightMean 26.4489
lHeightStd 4.5513
lHeightStdnorm 0.172079
lHeightMedian 25.038
lHeightQuartdelta 4.329
lHeightQuartdeltanorm 0.172897
lHeightKurt 4.5404
lHeightTrenddiff -3.51
lHeightTrendratio 0.872881
lAspectMean 0.290127
lAspectStd 0.0822479
lAspectStdnorm 0.283489
lAspectMedian 0.279197
lAspectQuartdelta 0.103302
lAspectQuartdeltanorm 0.369998
lAspectKurt 3.09309
lAspectTrenddiff 0.09833
lAspectTrendratio 1.40481
lSlantMean -0.0157964
lSlantStd 0.103749
lSlantStdnorm -6.56791
lSlantMedian -0.0208158
lSlantQuartdelta 0.160503
lSlantQuartdeltanorm -7.71061
lSlantKurt 1.98296
lSlantTrenddiff 0.114977
lRtopMean 0.718647
lRtopStd 0.15146
lRtopStdnorm 0.210757
lRtopMedian 0.747881
lRtopQuartdelta 0.21037
lRtopQuartdeltanorm 0.281288
lRtopKurt 2.73546
lRtopTrenddiff 0.178354
lRbotMean 0.85877
lRbotStd 0.312375
lRbotStdnorm 0.363748
lRbotMedian 0.726907
lRbotQuartdelta 0.525
lRbotQuartdeltanorm 0.722238
lRbotKurt 1.75
lRbotTrenddiff -0.497585
lRrightMean 0.860267
lRrightStd 0.0988729
lRrightStdnorm 0.114933
lRrightMedian 0.881287
lRrightQuartdelta 0.120018
lRrightQuartdeltanorm 0.136185
lRrightKurt 4.65976
lRrightTrenddiff 0.0434242
lRleftMean 0.349837
lRleftStd 0.150461
lRleftStdnorm 0.430089
lRleftMedian 0.320833
lRleftQuartdelta 0.17607
lRleftQuartdeltanorm 0.548791
lRleftKurt 2.73303
lRleftTrenddiff -0.155678

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.753524
sumTouchScores 18.0846
meanMovementTime 0.674783
numTouches 24
undershootPercentage 0
overshootPercentage 8.33333

FITTS Long Modified

meanTouchScore 0.768708
sumTouchScores 8.45579
meanMovementTime 1.5425
numTouches 11
undershootPercentage 0
overshootPercentage 9.09091

ZigZag

numZigzags 8
timePerZigzagMean 19.84
timePerZigzagCoV 0.172474
timePerZigzagSlope -0.0412346
meanError 5.19272
tremorFreq 6.25
tremorRelPower 31.4587
tremorGyroAmpMean 0.0343914
tremorGyroAmpSlope 0.00399673
tremorGyroAmpCoV 0.411295
tremorCoordAmpMean 0.133622
tremorCoordAmpSlope 0.0036715
tremorCoordAmpCoV 0.891625
tremorAccAmpMean 0.105171
tremorAccAmpSlope 0.00204161
tremorAccAmpCoV 0.219136
tremorPcRelVar 0.843269
tremorPcX 0.0536407
tremorPcY -0.99856

ZigZag Segment 1

Duration 26.76 s, Accuracy Estimate 5.72 (lower is better)

ZigZag Segment 2

Duration 17.32 s, Accuracy Estimate 7.45 (lower is better)

ZigZag Segment 3

Duration 21.4 s, Accuracy Estimate 7.087 (lower is better)

ZigZag Segment 4

Duration 21.6 s, Accuracy Estimate 4.559 (lower is better)

ZigZag Segment 5

Duration 16.32 s, Accuracy Estimate 5.083 (lower is better)

ZigZag Segment 6

Duration 19.68 s, Accuracy Estimate 4.836 (lower is better)

ZigZag Segment 7

Duration 16.92 s, Accuracy Estimate 3.907 (lower is better)

ZigZag Segment 8

Duration 18.72 s, Accuracy Estimate 2.899 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 17.496
timePerZigzagCoV 0.0930726
timePerZigzagSlope 0.026749
zigzagHeightMean 61.8664
zigzagHeightCoV 0.0814868
zigzagHeightSlope -0.0285856
meanError 0.0371921
tremorFreq 6.15234
tremorRelPower 24.2608
tremorGyroAmpMean 0.0408417
tremorGyroAmpSlope -0.00194267
tremorGyroAmpCoV 0.364489
tremorCoordAmpMean 0.130775
tremorCoordAmpSlope 0.0100591
tremorCoordAmpCoV 0.940337
tremorAccAmpMean 0.0973098
tremorAccAmpSlope 5.22012e-05
tremorAccAmpCoV 0.236564
tremorPcRelVar 0.90207
tremorPcX 0.0852735
tremorPcY -0.996358

ZigZag Offset Segment 1

Duration 17.76 s, Accuracy Estimate 0.055 (lower is better)

ZigZag Offset Segment 2

Duration 15.92 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 3

Duration 15.88 s, Accuracy Estimate 0.023 (lower is better)

ZigZag Offset Segment 4

Duration 19.72 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 5

Duration 18.2 s, Accuracy Estimate 0.05 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.79}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.6}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.8693171187822804}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.6373004938529674}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6635103089489831}